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Microbes in the Nasopharynx Prior to Lung Infection (MINOPOLI)
Microbes in the Nasopharynx Prior to Lung Infection (MINOPOLI) was a research program funded by National Health and Medical Research Council (NHMRC) to help determine the contribution that viruses and bacterial load make to respiratory disease. The research looked at the role of bacteria and viruses in lung infections and aimed to intervention to reduce the burden and consequences of lung infection in Indigenous children, in order to arrest preventable death in children.
Program objectives included:
- define the contribution of viral infection and increased bacterial load in the nose to episodes of lung infection in Indigenous children
- explore the role of respiratory human papilloma virus in lung infections in Indigenous children.
The research program was a collaboration between the Menzies School of Health Research, Monash University, the Alfred Hospital, Melbourne, the Queensland Children's Medical Research Institute and Queensland Health.
Abstract adapted from Menzies School of Health Research
Menzies School of Health Research
PO Box 41096
Casuarina NT 0811
Ph: (08) 8946 8600 (Reception)
Fax: (08) 8946 8464
Pickering J, Smith-Vaughan H, Beissbarth J, Bowman JM, Wiertsema S, Riley TV, Leach AJ, Richmond P, Lehmann D, Kirkham LS (2014)
Diversity of nontypeable Haemophilus influenzae colonizing Australian Aboriginal and non-Aboriginal children.
Journal of Clinical Microbiology; 52(5): 1352-1357
Smith-Vaughan HC, Chang AB, Sarovisch DS, Marsh RL, Grimwood K, Leach AJ, Price EP (2014)
Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae.
Clinical and Vaccine Immunology; 21(9): 250-252
Smith-Vaughan HC, Binks MJ, Marsh RL, Kaestli M, Ward L, Hare KM, Pizzutto SJ, Thornton RB, Morris PS, Leach AJ (2013)
Dominance of haemophilus influenzae in ear discharge from Indigenous Australian children with acute otitis media with tympanic membrane perforation.
BMC Ear, Nose and Throat Disorders; 13: 12
Retrieved 8 October 2013 from http://dx.doi.org/10.1186/1472-6815-13-12
Jafari HS, Adams WG, Robinson KA, Plikaytis BD, Wenger JD (1999)
Efficacy of Haemophilus influenzae type b conjugate vaccines and the persistence of disease in disadvantaged populations.
American Journal of Public Health; 89: 364-368
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