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Antecedents of Renal Disease in Aboriginal Children and Young Adults (ARDAC) study
The Antecedents of Renal Disease in Aboriginal Children and Young Adults (ARDAC) study is a community-based, longitudinal, cohort study which monitors the heart health of children and young people in New South Wales (NSW).
There are two project aims:
- to determine the prevalence of persistent risk factors for chronic kidney and heart disease in Aboriginal and non-Aboriginal children and young people
- to determine whether the increased risk of chronic kidney and heart disease found in Aboriginal Australian adults is evident in Aboriginal children by a higher risk for the early markers of these chronic diseases.
The first phase of the ARDAC study has been completed, with no differences found in the prevalence and incidence of markers of chronic kidney disease, along with no increased risk for cardiovascular disease in Indigenous children as compared to non-Indigenous children. Researchers hypothesised that the increased risk for chronic disease seen in Indigenous adults may start to manifest in older Indigenous children and young Indigenous adults, and proposed to follow the phase one cohort for a longer time period.
This second phase study will follow the Indigenous and non-Indigenous participants from the first phase study into young childhood for a further six years, with three sets of tests administered that will each be two years apart. There will also be the additional recruitment of new high school participants and other sources during the first round of testing, so as to maintain study power. These tests will aid in:
- determining whether young Indigenous adults from diverse geographical areas develop an increase risk of chronic kidney disease and cardiovascular disease as compared with non-Indigenous young adults
- determining whether socio-demographic determinants of health have any association with risk for these chronic diseases.
The study has a website providing information on the study, objectives, research team, data collection and publications.
Abstract adapted from the Centre for Kidney Health Research
Kids Research Institute (Centre for Kidney Research)
Level 2, Corner Hawkesbury Road and Hainsworth Street
The Children's Hospital at Westmead 2145
Locked Bag 4001
Westmead NSW 2145
Ph: (02) 9845 1469
Ph: 1800 005 846 (free call)
Fax: (02) 9845 1491
Haysom L, Williams R, Hodson E, Lopez-Vargas P, Roy LP, Lyle D, Craig JC (2009)
Risk of CKD in Australian Indigenous and non-Indigenous children: a population-based cohort study.
American Journal of Kidney Diseases; 53(2): 229-237
Haysom L, Williams RE, Hodson EM, Lopez-Vargas P, Roy LP, Lyle DM, Craig JC (2009)
Cardiovascular risk factors in Australian Indigenous and non-Indigenous children: a population-based study.
Journal of Paediatrics and Child Health; 45(1-2): 20-27
Haysom L, Williams R, Hodson EM, Lopez-Vargas PA, Roy LP, Lyle DM, Craig JC (2009)
Natural history of chronic kidney disease in Australian Indigenous and non-Indigenous children: a 4-year population-based follow-up study.
Medical Journal of Australia; 190(6): 303-306
Haysom L, Williams R, Hodson E, Lopez-Vargas P, Roy LP, Lyle D, Craig JC (2008)
Diagnostic accuracy of urine dipsticks for detecting albuminuria in Indigenous and non-Indigenous children in a community setting.
Pediatric Nephrology; 24(2): 323-331
Haysom L (2008)
Antecedents of renal disease in Aboriginal children.
Doctor of Philosophy thesis, University of Sydney: Sydney
Haysom L, Williams R, Hodson E, Roy LP, Lyle D, Craig JC (2007)
Early chronic kidney disease in Aboriginal and non-Aboriginal Australian children: remoteness, socioeconomic disadvantage or race?.
Kidney International; 71(8): 787-794
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