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Multi-centre Bronchiectasis Study: a Collaborative and International Study of Bronchiectasis in Indigenous Children
The Menzies School of Health Research in collaboration with national and international research teams is involved in this project which examines bronchiectasis in Indigenous children. In Australia, team members will visit Indigenous communities in the central and top end regions of Australia.
There are two parts to the project. An observational study aims to define the natural history of bronchiectasis and chronic moist cough and then identify the risk factors associated with the progression of an early/mild disease to bronchiectasis. The second part of the project is an intervention study which will evaluate the effectiveness of antibiotic treatment, and antibiotic resistance.
The study will provide an evidence base to assist in the development of future policy initiatives to combat the rates of morbidity and mortality relating to chronic and recurring respiratory illnesses in Indigenous children.
Participation in the research will also hopefully contribute to the improvement of the health outcomes for the children as they will be part of appropriate diagnostic assessments, reviews and treatment plans.
Abstract adapted from the Lowitja Institute
Valery PC, Morris PS, Grimwood K, Torzillo PJ, Byrne CA, Masters BI, Bauert PA, McCallum GB, Mobberly C, Chang AB (2012)
Azithromycin for Indigenous children with bronchiectasis: study protocol for a multi-centre randomized controlled trial.
BMC Pediatrics; 12: 122
Retrieved 14 August 2012 from http://dx.doi.org/10.1186/1471-2431-12-122
Singleton RJ, Valery PC, Morris P, Byrnes CA, Grimwood K, Redding G, Torzillo PJ, McCallum G, Chikoyak L, Mobberly C, Holman RC, Chang AB (2014)
Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis.
Pediatric Pulmonology; 49(2): 189–200
Valery PC, Morris PS, Byrnes CA, Grimwood K, Torzillo PJ, Bauert PA, Masters IB, Diaz A, McCallum GB, Mobberley C, Tjhung I, Hare KM, Ware RS, Chang AB (2013)
Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial.
The Lancet Respiratory Medicine; 1(8): 610–620
Hare KM, Singleton RJ, Grimwood K, Valery PC, Cheng AC, Morris PS, Leach AJ, Smith-Vaughan HC, Chatfield M, Redding G, Reasonover AL, McCallum GB, Chikoyak L, McDonald MI, Brown N, Torzillo PJ, Chang AB (2013)
Longitudinal nasopharyngeal carriage and antibiotic resistance of respiratory bacteria in Indigenous Australian and Alaska native children with bronchiectasis.
PLOS ONE; 8(8): e70478
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