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It is anticipated that the project will make an important contribution in the shift toward more effective prevention and management of otitis media in Aboriginal children. It will also have implications for all disadvantaged populations where adverse outcomes are common and compliance with recommended treatment is poor.
Project aim:
In this randomised controlled trial, the benefits of two doses of azithromycin given one week apart in children with asymptomatic acute otitis media, will be determined. The results of the trial will become the best available evidence to guide the medical management of asymptomatic acute otitis media (AOM) in high-risk children.
Focus area:
Remote Indigenous children
Project activities:
In a previous antibiotic study, acute otitis media (AOM) persisted in 50% of children after 1 week of treatment. In terms of clinical success, it didn't make any difference whether azithromycin or amoxicillin was used (although azithromycin seemed to be better at reducing the level of infection). Currently local clinicians are: i) uncertain whether antibiotics make any difference at all; and ii) reluctant to devote resources to case-finding without good evidence of substantial benefit.
Participant recruitment is continuing in the Top End and recruitment in Central Australian communities will commence in early 2010. The aim is to have randomised 380 children (the target) by the end of 2010. Preliminary analysis will then be provided to all local investigators and feedback to all communities contributing children to the trial. Preparation of reports, scientific presentations and submissions for publication will occur January - June 2011.
Child Health Division
Menzies School of Health Research
PO Box 41096
Casurina NT 0811
Ph: (08) 8922 8196
Fax: (08) 8927 5187
Email: earinfonet@menzies.edu.au
