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        • » A vulvar cancer cluster caused by genetic susceptibility: investigating the genetic mechanism (formerly A vulvar cancer cluster in young Indigenous women in Arnhem Land: investigation of community knowledge, genetic susceptibility and supportive care

A vulvar cancer cluster caused by genetic susceptibility: investigating the genetic mechanism (formerly A vulvar cancer cluster in young Indigenous women in Arnhem Land: investigation of community knowledge, genetic susceptibility and supportive care

 

Overview

Menzies School of Health Research is conducting this research project to determine the cause of the epidemic of vulvar cancer in young Indigenous women living in remote Northern Territory (NT) communities. The research aims to investigate the regions of Deoxyribonucleic acid (DNA) highlighted by genetic studies in order to identify the genetic variant or variants responsible for the increased incidence of vulvar cancer in communities and how they work.

The research team collaborates with health care providers, the NT Department of Health and other researchers Australia-wide, to identify this disease and improve preventive and treatment strategies and increase awareness of the problem.

The National Health and Medical Research Council has awarded the project a grant to continue for the period 2014-2016 which will include any new cases as they arise and new analytical methods.

Abstract adapted from Menzies School of Health Research

Contacts

Rebekah McWhirter
Project Manager
Menzies School of Health Research
PO Box 41096
Casuarina NT 0811
Ph: (08) 8922 8196 (Reception)
Fax: (08) 8927 5187
Email: rebekah.mcwhirter@utas.edu.au

Related publications

Condon JR, Rumbold AR, Thorn JC, O'Brien MM, Davy MJ, Zardawi I (2009)

A cluster of vulvar cancer and vulvar intraepithelial neoplasia in young Australian Indigenous women.

Cancer Causes & Control; 20(1): 67-74

McGrath P, Rawson N, Adidi L (2015)

Diagnosis and treatment for vulvar cancer for Indigenous women from east Arnhem Land, Northern Territory: bioethical reflections.

Journal of Bioethical Inquiry; 12(2): 343-352

McWhirter RE, Mununggirritj D, Marika D, Dickinson JL, Condon JR (2012)

Ethical genetic research in Indigenous communities: challenges and successful approaches.

Trends in Molecular Medicine; 18(12): 702–708

Rumbold AR, Tan SE, Condon JR, Taylor-Thomson D, Nickels M, Tabrizi SN, Davy ML, O'Brien MM, Connors CM, Zardawi I, Stankovich J, Garland SM (2012)

Investigating a cluster of vulvar cancer in young women: a cross-sectional study of genital human papillomavirus prevalence.

BMC Infectious Diseases; 12: 243

Retrieved 5 October 2012 from http://www.biomedcentral.com/1471-2334/12/243

Tan SE, Garland SM, Rumbold AR, Zardawi I, Taylor-Thomson D, Condon JR, Tabrizi SN (2013)

Investigating a cluster of vulvar cancers in young women: distribution of human papillomavirus and HPV-16 variants in vulvar dysplastic or neoplastic biopsies.

Sexual Health; 10(1): 18-25

McWhirter RE, Thomson RJ, Marthick JR, Rumbold AR, Brown MA, Taylor-Thomson D, Maypilama EL, Condon JR, Dickinson JL (2014)

Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women.

Gynecologic Oncology; 133(3): 421–426

McGrath P, Rawson N (2013)

The experience of relocation for specialist treatment for Indigenous women diagnosed with vulvar cancer in East Arnhem Land.

Journal of Psychosocial Oncology; 31(5): 540-555

Links

 
Last updated: 13 June 2016
 
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