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        • » Randomised Controlled Trial of Azithromycin to Reduce the Morbidity of Severe Bronchiolitis in Young Indigenous Children

Randomised Controlled Trial of Azithromycin to Reduce the Morbidity of Severe Bronchiolitis in Young Indigenous Children



This research investigated bronchiolitis in young Indigenous children and the clinical effectiveness of the drug azithromycin compared with a placebo in treating the illness. In addition to this primary investigation the research also looked at other issues relating to acute lower respiratory tract infections in Indigenous children, specifically:

The research found that despite reducing nasopharyngeal bacterial carriage, three large once-weekly doses of azithromycin did not confer any benefit over placebo during the bronchiolitis illness or 6 months post hospitalization. Azithromycin should not be used routinely to treat infants hospitalized with bronchiolitis.

*Macrolide is one in a class of antibiotics that inhibits the growth of bacteria and is often prescribed to treat common bacterial infections.

Abstract adapted from Menzies School of Health Research


Menzies School of Health Research

Related publications

McCallum GB, Chatfield MD, Morris PS, Chang AB (2016)

Risk factors for adverse outcomes of Indigenous infants hospitalized with bronchiolitis.

Pediatric Pulmonology; 51(6): 613-623

McCallum GB, Morris PS, Grimwood K, Maclennan C, White AV, Chatfield MD, Sloots TP, Mackay IM, Smith-Vaughan H, McKay CC, Versteegh LA, Jacobsen N, Mobberley C, Byrnes CA, Chang AB (2015)

Three-weekly doses of azithromycin for indigenous infants hospitalized with bronchiolitis: a multicentre, randomized, placebo-controlled trial.

Frontiers in Pediatrics; 3(32): 1-9

McCallum GB, Morris PS, Wilson CC, Versteegh LA, Ward LM, Chatfield MD, Chang AB (2013)

Severity scoring systems: are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis?.

Pediatric Pulmonology; 48(8): 797–803


Last updated: 13 September 2016
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