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The Kanyini Guidelines Adherence with the Polypill study - Kanyini GAP



This randomised controlled clinical trial aimed to investigate if a polypill (single pill containing fixed-dose combination of treatments) would improve the adherence and health outcomes of patients with cardiovascular disease, as opposed to those using standard interventions.

It was proposed that a polypill could improve adherence to recommended treatment by reducing overall complexity of treatment for doctors and patients, and improve access by reducing costs.

The research involved 1,000 Indigenous patients at risk of a cardiovascular event determined by a formal assessment process. It was conducted in Aboriginal Community Controlled Health Services and general medical practices in Australia. Participants in the study were monitored for approximately 18 months.

Abstract adapted from the George Institute for Global Health


Professor Anushka Patel
Chief Scientist
The George Institute for Global Health
Head Office
Level 13, 321 Kent Street
Sydney NSW 2000
Ph: (02) 8238 2439
Ph: (02) 9657 0300
Fax: (02) 9657 0301

Related publications

Angell B, Laba TL, Lung T, Brown A, Eades S, Usherwood T, Peiris D, Billot L, Hillis G, Webster R, Tonkin A, Reid C, Molanus B, Rafter N, Cass A, Patel A, Jan S (2017)

Healthcare expenditure on Indigenous and non-Indigenous Australians at high risk of cardiovascular disease.

International Journal for Equity in Health; 16: 108

Retrieved 23 June 2017 from

Anushka P, Cass A, Peiris D, Usherwood T, Brown A, Jan S, Neal B, Hillis GS, Rafter N, Tonkin A, Webster R, Billot L, Bompoint S, Burch C, Burke H, Hayman N, Molanus B, Reid CM, Shiel L, Togni S, Rodgers A (2015)

A pragmatic randomized trial of a polypill-based strategy to improve use of indicated preventive treatments in people at high cardiovascular disease risk.

European Journal of Preventive Cardiology; 22(7): 920-930

Liu H, Massi L, Laba TL, Peiris D, Usherwood T, Patel A, Cass A, Eades AM, Redfern J, Hayman N, Howard K, Brien JA, Jan S (2015)

Patients' and providers' perspectives of a polypill strategy to improve cardiovascular prevention in Australian primary health care: a qualitative study set within a pragmatic randomized, controlled trial.

Circulation: Cardiovascular Quality and Outcomes; Online before print(

Liu H, Laba T-L, Massi L, Jan S, Usherwood T, Patel A, Hayman NE, Cass A, Eades A-M, Lawrence C, Peiris DP (2015)

Facilitators and barriers to implementation of a pragmatic clinical trial in Aboriginal health services.

Medical Journal of Australia; 203(1): 24-27

Liu H, Patel A, Brown A, Eades S, Hayman N, Jan S, Ring I, Stewart G, Tonkin A, Weeramanthri T, Wade V, Rodgers A, Usherwood T, Neal B, Peiris D, Burke H, Reid C, Cass A (2010)

Rationale and design of the Kanyini guidelines adherence with the polypill (Kanyini-GAP) study: a randomised controlled trial of a polypill-based strategy amongst Indigenous and non Indigenous people at high cardiovascular risk.

BMC Public Health; 10: 458

Retrieved from


Last updated: 3 July 2017
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