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Vitamin D Insufficiency in Indigenous Infants and the Risk of Hospitalisation for Acute Lower Respiratory Infection (ALRI)
The primary aim of the study was to determine if vitamin D insufficiency in cord blood is associated with a higher risk of hospitalisation for ALRI during the first year of life.
The secondary aims of the study were:
- To examine the association between vitamin D insufficiency in cord blood and pathogen density in the nasopharynx at one month of age.
- To examine the association between vitamin D insufficiency in cord blood and the infant response to childhood pneumococcal conjugate vaccination (PCV) assessed at 7 months of age.
- To examine the association between maternal and infant serum vitamin D levels at birth and the influence of vitamin D levels in breast milk on vitamin D levels in infant serum at 7 months post partum.
The study found that cord blood vitamin D concentrations were approximately half that of maternal blood in the third trimester of pregnancy (~7 weeks earlier). Most (80%) cord bloods were vitamin D insufficient (
Abstract adapted from Menzies School of Health Research
Child Health Division
Respiratory and Ear Health Teams
Menzies School of Health Research
Ph: (08) 892 27646
Binks MJ, Smith-Vaughan HC, Marsh R, Chang AB, Andrews RM (2016)
Cord blood vitamin D and the risk of acute lower respiratory infection in Indigenous infants in the Northern Territory.
Medical Journal of Australia; 204(6): 238e1-238e7
Binks MJ, Smith-Vaughan HC, Bar-Zeev N, Chang AB, Andrews RM (2014)
Vitamin D insufficiency among hospitalised children in the Northern Territory.
Journal of Paediatrics and Child Health; 50(7): 512–518
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